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Article

Rapamycin alleviates pathogenesis of a new Drosophila model of ALS-TDP.

Journal of neurogenetics - 1 Jan 2015

Cheng Ching-Wei, Lin Meng-Jau, Shen Che-Kun James

Abstract excerpt

TDP-43 is a multi-functional RNA/DNA-binding protein, well-conserved among many species including mammals and Drosophila. However, it is also a major component of the pathological inclusions associated with degenerating motor neurons of amyotrophic lateral sclerosis (ALS). Further, TDP-43 is a signature protein in one subtype of frontotemporal degeneration, FTLD-U. Currently, there are no effective drugs for...

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Identifiers

PMID: 26219309
DOI: 10.3109/01677063.2015.1077832

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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