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Reprogramming the anti-tumor immune response via CRISPR genetic and epigenetic editing

24 Apr 2021

Abstract excerpt

Precise clustered regularly interspaced short palindromic repeats (CRISPR)-mediated genetic and epigenetic manipulation of the immune response has become a promising immunotherapeutic approach toward combating tumorigenesis and tumor progression. CRISPR-based immunologic reprograming in cancer therapy comprises the locus-specific enhancement of host immunity, the improvement of tumor immunogenicity, and the...

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PMID: 34095343
DOI: 10.1016/j.omtm.2021.04.009

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