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CRISPR screens in the context of immune selection identify <i>CHD1</i> and <i>MAP3K7</i> as mediators of cancer immunotherapy resistance

2025-04-18

Abstract excerpt

<h4>Summary</h4> Cancer immunotherapy is only effective in a subset of patients, highlighting the need for effective biomarkers and combination therapies. Here we systematically identify genetic determinants of cancer cell sensitivity to anti-tumor immunity by performing whole-genome CRISPR/Cas9 knock-out screens in autologous tumoroid-T cell co-cultures, isogenic cancer cell models deficient in interferon signal...

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Literature Corpus work
33c36c89-979b-52e6-b2c7-d4a4b7e73319
DOI
10.1101/2025.04.15.648737
Open publication

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CRISPR screens in the context of immune selection identify <i>CHD1</i> and <i>MAP3K7</i> as mediators of cancer immunotherapy resistanceDOI 10.1101/2025.04.15.648737
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