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Tissue spaces are reservoirs of antigenic diversity for Trypanosoma brucei

30 Oct 2024

Abstract excerpt

Abstract The protozoan parasite Trypanosoma brucei evades clearance by the host immune system through antigenic variation of its dense variant surface glycoprotein (VSG) coat, periodically ‘switching’ expression of the VSG using a large genomic repertoire of VSG-encoding genes 1–6 . Recent studies of antigenic variation in vivo have focused near exclusively on parasites in the bloodstream 6–8 , but research has...

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PMID: 39478231
DOI: 10.1038/s41586-024-08151-z

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