Article
DNA Recombination Strategies During Antigenic Variation in the African Trypanosome.
Microbiology spectrum - 1 Apr 2015
McCulloch Richard, Morrison Liam J, Hall James P J
Abstract excerpt
Survival of the African trypanosome in its mammalian hosts has led to the evolution of antigenic variation, a process for evasion of adaptive immunity that has independently evolved in many other viral, bacterial and eukaryotic pathogens. The essential features of trypanosome antigenic variation have been understood for many years and comprise a dense, protective Variant Surface Glycoprotein (VSG) coat, which can...
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