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Article

Induction and Repair of Clustered DNA Lesions: What Do We Know So Far?

17 May 2013

Abstract excerpt

The accumulated evidence in the literature indicates that a cluster of two or more lesions within one or two helical turns of the DNA is more challenging to repair than individual, widely dispersed lesions. The biological importance of clustered DNA lesions, especially complex double-strand breaks (DSB) and some types of non-DSB clusters (e.g., opposed bases that are oxidized), are now well known within the...

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PMID: 23682596
DOI: 10.1667/rr3041.1

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