Article
Oxidative DNA damage and disease: induction, repair and significance.
Mutation research - 1 Sept 2004
Evans Mark D, Dizdaroglu Miral, Cooke Marcus S
Abstract excerpt
The generation of reactive oxygen species may be both beneficial to cells, performing a function in inter- and intracellular signalling, and detrimental, modifying cellular biomolecules, accumulation of which has been associated with numerous diseases. Of the molecules subject to oxidative modification, DNA has received the greatest attention, with biomarkers of exposure and effect closest to validation. Despite...
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