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Vascular Regulation of Hematopoietic Stem Cell Homeostasis, Regeneration, and Aging

4 Sept 2021

Abstract excerpt

PURPOSE OF REVIEW: Hematopoietic stem cells (HSCs) sit at the top of the hierarchy that meets the daily burden of blood production. HSC maintenance relies on extrinsic cues from the bone marrow (BM) microenvironment to balance stem cell self-renewal and cell fate decisions. In this brief review, we will highlight the studies and model systems that define the centralized role of BM vascular endothelium in...

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PMID: 34868826
DOI: 10.1007/s40778-021-00198-2

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