Article

Pan-cancer HLA Gene-mediated Tumor Immunogenicity and Immune Evasion

2021-05-18

Abstract excerpt

Human Leukocyte Antigen (HLA) expression contributes to the activation of anti-tumor immunity through interactions with T cell receptors. However, pan-cancer HLA-mediated immunogenicity and immunoediting mechanisms has not been systematically studied. In a retrospective analysis of 33 tumor types from the Cancer Genome Atlas, we uncovered HLA class I and class II differential expression, which outperformed traditi...

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Literature Corpus work: 2c1342b3-90ab-586e-a71e-0142e141444a
DOI: 10.1101/2021.05.17.444511

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