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Allele-specific HLA LOH in solid tumors: distinct patterns by tumor type and potential prognostic relevance.

Journal for immunotherapy of cancer - 9 Sept 2025

Sewastianik Tomasz, Roy Christian, Gormally Michael V, Montesion Meagan, Halvey Patrick, Jindal Aastha, Lam Hubert, Schoenfeld Adam, Klebanoff Christopher A, Opiteck Gregory J, Nagorsen Dirk

Abstract excerpt

T-cell receptors (TCRs) recognize antigens derived from fragments of somatically expressed proteins that are degraded by the proteasome and presented by specific human leukocyte antigen (HLA) molecules. Recent therapeutic advances using the TCR as a tumor-targeting moiety have focused attention on HLA loss of heterozygosity (LOH) as a potential resistance mechanism. Allele-specific LOH, rather than...

Topics

Humans
Loss of Heterozygosity
Prognosis
Alleles
Neoplasms
HLA Antigens
Female
Male

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 40930743
DOI: 10.1136/jitc-2025-012435
PMCID: PMC12421593

Genes

KRAS
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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