Article
Germline HLA-B evolutionary divergence influences the efficacy of immune checkpoint blockade therapy in gastrointestinal cancer.
Genome medicine - 3 Nov 2021
Lu Zhihao, Chen Huan, Jiao Xi, Wang Yujiao, Wu Lijia, Sun Huaibo, Li Shuang, Gong Jifang, Li Jian, Zou Jianling, Yang Keyan, Hu Ying, Mao Beibei, Zhang Lei, Zhang Xiaotian, Peng Zhi, Lu Ming, Wang Zhenghang, Zhang Henghui, Shen Lin
Abstract excerpt
BACKGROUND: The human leukocyte antigen class I (HLA-I) genotype has been linked with differential immune responses to infectious disease and cancer. However, the clinical relevance of germline HLA-mediated immunity in gastrointestinal (GI) cancer remains elusive. METHODS: This study retrospectively analyzed the genomic profiling data from 84 metastatic GI cancer patients treated with immune checkpoint blockade...
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