Article

The buried S2 apex of SARS-CoV-2 spike elicits an immunodominant germline-restricted public antibody response

2026-02-19

Abstract excerpt

<h4>SUMMARY</h4> The continued mutational pressure on the SARS-CoV-2 S1 subunit underscores the need to target the conserved S2 region for pan-coronavirus vaccine development. A detailed molecular understanding of S2-directed immune responses is therefore essential. In this study, we identified the S2 apex as the most immunodominant epitope within the S2 subunit, eliciting robust antibody responses despite occlus...

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Literature Corpus work: 454f8ad4-7fa2-5f92-8a3f-cce5d89dc9e1
DOI: 10.64898/2026.02.18.706653

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