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Mining Alzheimer's Interactomes, Macromolecular Complexes and Pathways for Drug Discovery.

Proteomics - 1 Nov 2025

Panneerselvam Kalpana, Tiwari Krishna Kumar, Licata Luana, Panni Simona, Ricard-Blum Sylvie, Balu Sucharitha, Huget Susie, Medina Reyes Juan Jose, Ragueneau Eliot, Perfetto Livia, Meldal Birgit, Orchard Sandra, Hermjakob Henning

Abstract excerpt

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to dementia. Many cases are diagnosed annually and there is no currently available cure. Understanding the underlying disease biology of AD through the study of molecular networks, particularly by mapping clinical variants to tissue-specific interactomes and regulatory macromolecular assemblies, offers a promising avenue to elucidate...

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PMID: 40855644
DOI: 10.1002/pmic.70018
PMCID: PMC12645816

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APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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