Article

Human xenobiotic metabolism proteins have full-length and split homologs in the gut microbiome

2024-11-08

Abstract excerpt

Xenobiotics, including pharmaceutical drugs, can be metabolized by both host and microbiota, in some cases by homologous enzymes. We conducted a systematic search for all human proteins with gut microbial homologs. Because gene fusion and fission can obscure homology detection, we built a pipeline to identify not only full-length homologs, but also cases where microbial homologs were split across multiple adjacent...

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Literature Corpus work: 45388c68-2f53-55b1-970f-cfb9cef285dc
DOI: 10.1101/2024.11.06.622278

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