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Aldo-keto reductase (AKR) superfamily: Genomics and annotation

1 Jul 2009

Abstract excerpt

Aldo-keto reductases (AKRs) are phase I metabolising enzymes that catalyse the reduced nicotinamide adenine dinucleotide (phosphate) (NAD(P)H)-dependent reduction of carbonyl groups to yield primary and secondary alcohols on a wide range of substrates, including aliphatic and aromatic aldehydes and ketones, ketoprostaglandins, ketosteroids and xenobiotics. In so doing they functionalise the carbonyl group for...

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PMID: 19706366
DOI: 10.1186/1479-7364-3-4-362

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