Article

Discovery of the metalloenzyme IsmB revises a pathway for coprostanol formation by the human gut microbiome

2025-12-30

Abstract excerpt

<h4>SUMMARY</h4> High levels of circulating cholesterol are associated with human cardiovascular diseases and an altered gut microbiome. Still, major gaps exist in our understanding of the interactions of cholesterol with gut microbes. The reductive transformation of cholesterol to the poorly absorbed sterol coprostanol by human gut bacteria has long been known, but the genetic and biochemical basis for this acti...

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Literature Corpus work: 43cdffb4-101c-512a-b889-89d6ce652228
DOI: 10.64898/2025.12.29.696961

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