Article

Diverse but Desolate Landscape of Gut Microbial Azoreductases: A Rationale for Idiopathic IBD Drug Response

2022-12-05

Abstract excerpt

<h4>Background: </h4> Prodrugs reliant on microbial activation are widely used but exhibit a range of efficacies that remain poorly understood. The anti-inflammatory compound 5-aminosalicylic acid (5-ASA), which is packaged in a variety of azo-linked prodrugs provided to most Ulcerative Colitis (UC) patients, show confounding inter-individual variabilities in response. Such prodrugs must be activated by azo-bond r...

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Literature Corpus work: 4c7898d7-9f4a-5d30-bd5a-903dc7522dc2
DOI: 10.21203/rs.3.rs-2326828/v1

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