Article

Cell-type specific impact of glucocorticoid receptor activation on the developing brain

2020-01-09

Abstract excerpt

A fine-tuned balance of glucocorticoid receptor (GR) activation is essential for organ formation, with disturbances influencing health outcomes. Excess GR-activation in utero has been linked to brain-related negative outcomes, with unclear underlying mechanisms, especially regarding cell-type specific effects. To address this, we used an in vitro model of fetal human brain, induced pluripotent-stem-cell-derived...

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Literature Corpus work: 7a730191-478a-52a3-9a98-f8b93149e376
DOI: 10.1101/2020.01.09.897868

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