Article

Human neurogenesis is altered via glucocorticoid-mediated regulation of <i>ZBTB16</i> expression

2022-08-22

Abstract excerpt

<h4>Summary</h4> Glucocorticoids are important for proper organ maturation and their levels are tightly regulated during development. Here we use human cerebral organoids and mice to study cell-type specific effects of glucocorticoids on neurogenesis. We show that glucocorticoids increase a specific type of basal progenitors (co-expressing PAX6 and EOMES ) that has been shown to drive cortical expansion in gyri...

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Literature Corpus work: 37b9cb55-828a-5486-bb04-4fd0a8e226e0
DOI: 10.1101/2022.08.21.504700

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