Article

High-content profiling reveals a unified model of copper ionophore dependent cell death in oesophageal adenocarcinoma

2021-10-06

Abstract excerpt

<h4>Background and Aims</h4> Oesophageal adenocarcinoma (OAC) is of increasing global concern due to increasing incidence, a lack of effective treatments, and poor prognosis. Therapeutic target discovery and clinical trials have been hindered by the heterogeneity of the disease, lack of driver mutations, and the dominance of large-scale genomic rearrangements. In this work we have characterised three potent and s...

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Literature Corpus work: 4508fae9-256c-5523-88d1-45d21b712a54
DOI: 10.1101/2021.10.05.463189

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