High-resolution phenotypic profiling of natural products-induced effects on the single-cell level.

Abstract excerpt

Natural products (NPs) are highly evolved molecules making them a valuable resource for new therapeutics. Here we demonstrate the usefulness of broad-spectrum phenotypic profiling of NP-induced perturbations on single cells with imaging-based High-Content Screening to inform on physiology, mechanisms-of-actions, and multi-level toxicity. Our technology platform aims at broad applicability using a comprehensive...

Topics

Join the communities discussing this publication.

• Biological Products
• HeLa Cells
• High-Throughput Screening Assays
• Phenotype
• Single-Cell Analysis