High content profiling in oesophageal adenocarcinoma to inform drug discovery and patient stratification

Abstract excerpt

Oesophageal adenocarcinoma (OAC) is a highly heterogeneous disease, dominated by copy number alterations and large-scale genomic rearrangements. Such characteristics have hampered both therapeutic target discovery and the clinical success of targeted therapies, contributing to its status as an area of unmet therapeutic need. Phenotypic drug discovery describes the screening and selection of hit or lead compounds b...

Topics

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• Adenocarcinoma
• Drug Discovery
• Drug Repositioning
• Esophageal Neoplasms
• Gene Expression Profiling
• Machine Learning
• Molecular Imaging
• Small Molecule Libraries

Identifiers and source

Literature Corpus work

f6100339-9d52-5112-98b2-4e5eb0ba3dac

DOI

10.7488/era/1181