Article
Multiparametric High-Content Cell Painting Identifies Copper Ionophores as Selective Modulators of Esophageal Cancer Phenotypes.
ACS chemical biology - 15 Jul 2022
Hughes Rebecca E, Elliott Richard J R, Li Xiaodun, Munro Alison F, Makda Ashraff, Carter Roderick N, Morton Nicholas M, Fujihara Kenji, Clemons Nicholas J, Fitzgerald Rebecca, O'Neill J Robert, Hupp Ted, Carragher Neil O
Abstract excerpt
Esophageal adenocarcinoma is of increasing global concern due to increasing incidence, a lack of effective treatments, and poor prognosis. Therapeutic target discovery and clinical trials have been hindered by the heterogeneity of the disease, the lack of "druggable" driver mutations, and the dominance of large-scale genomic rearrangements. We have previously undertaken a comprehensive small-molecule phenotypic...
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