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Article

Copper ionophore elesclomol selectively targets GNAQ/11-mutant uveal melanoma.

Oncogene - 1 Jul 2022

Li Yongyun, Yang Jie, Zhang Qianqian, Xu Shiqiong, Sun Wei, Ge Shengfang, Xu Xiaowei, Jager Martine J, Jia Renbing, Zhang Jianming, Fan Xianqun

Abstract excerpt

Unlike cutaneous melanoma, uveal melanoma (UM) is characterized by mutations in GNAQ and GNA11 and remains a fatal disease because there is essentially no effective targeted therapy or immunotherapy available. We report the discovery of the copper ionophore elesclomol as a GNAQ/11-specific UM inhibitor. Elesclomol was identified in a differential cytotoxicity screen of an in-house tool compound library, and its...

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PMID: 35697803
DOI: 10.1038/s41388-022-02364-0

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