Article

Targeting the TLK1-Nek1-Mediated Activation of YAP1 Attenuates PD-L1 and Anti-Inflammation Set for Prostate Cancer Immunoevasion

2025-10-01

Abstract excerpt

Our recent studies on the activation of the TLK1B>NEK1>YAP1 axis following ADT/ARSI have revealed the outlines of an innate immunity integration response that includes PD-L1 expression and alterations in cGAS-pSTING and pSTAT1/3, which drive the immunoevasion of PCa cells after prolonged treatment with ARSI and can thus contribute to CRPC progression. These observations are consistent with the general assess...

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Literature Corpus work: 44f98aec-ed10-5d11-bbd3-22c75d4338be
DOI: 10.20944/preprints202505.1821.v3

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