Article

Prioritization of prostate cancer to immune checkpoint therapy by ranking tumors along IFN-γ axis and identification of immune resistance mechanisms

2020-10-19

Abstract excerpt

We propose priotirization of prostate cancer patients to PD-L1 checkpoint therapy by assessing activity of IFN-γ/PD-L1 signaling in tumor from transcriptional profile. To this end, we introduced a new approach for inferring pathway activity and suppression (IPAS) by assessing significance of positioning pathway’s genes expression levels at top (activation) or bottom (suppression) in gene expression profile of a gi...

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Literature Corpus work: 90ec619e-d37e-5a95-b394-1c30d5eb0cfd
DOI: 10.1101/2020.10.19.345629

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