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Article

The TLK1>Nek1 Axis Promotes Nuclear Retention and Activation of YAP with Implications for CRPC

2024-07-22

Abstract excerpt

Despite some advances in controlling progression of Prostate Cancer (PCa) that is refractory to the use of ADT/ARSI, most patients eventually succumb to the disease, and there is a pressing need to understand the mechanisms that lead to the development of CRPC. A common mechanism is the ability to integrate AR signals from vanishing levels of testosterone, with the frequent participation of YAP as a coactivator, a...

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Literature Corpus work
7c3afd53-c65f-5526-89c0-34d53b94299d
DOI
10.20944/preprints202407.1709.v1
Open publication

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