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Paralogous guanine deaminases acquired from bacteria by horizontal gene transfer promote purine homeostasis in <i>Caenorhabditis elegans</i>

2026-04-12

Abstract excerpt

Disruptions in purine metabolism contribute to a range of human diseases, from rare genetic disorders such as Lesch-Nyhan syndrome and xanthinuria to common conditions including gout and cancer. To better understand the metabolic networks that regulate purine homeostasis, we developed a Caenorhabditis elegans model of xanthine dehydrogenase ( xdh-1 ) deficiency. Remarkably, xdh-1 mutant animals form rare xanthi...

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Literature Corpus work
44f276a3-5a2d-5a04-a560-a4d53e987982
DOI
10.64898/2026.04.09.715363
Open publication

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Paralogous guanine deaminases acquired from bacteria by horizontal gene transfer promote purine homeostasis in <i>Caenorhabditis elegans</i>DOI 10.64898/2026.04.09.715363
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