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XDH-1 inactivation causes xanthine stone formation in <i>C. elegans</i> which is inhibited by SULP-4-mediated anion exchange in the excretory cell

2025-01-27

Abstract excerpt

Xanthine dehydrogenase (XDH) is a molybdenum cofactor (Moco) requiring enzyme that catabolizes hypoxanthine into xanthine and xanthine into uric acid, the final steps in purine catabolism. Human patients with mutations in XDH develop xanthinuria which can lead to xanthine stones in the kidney, recurrent urinary tract infections, and renal failure. Currently there are no therapies for treating human XDH deficiency....

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Literature Corpus work
0900754b-575a-5a27-83d5-a2580b3e4614
DOI
10.1101/2025.01.24.634556
Open publication

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XDH-1 inactivation causes xanthine stone formation in <i>C. elegans</i> which is inhibited by SULP-4-mediated anion exchange in the excretory cellDOI 10.1101/2025.01.24.634556
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