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Article

idh-1 neomorphic mutation confers sensitivity to vitamin B12 in Caenorhabditis elegans.

Life science alliance - 1 Oct 2024

Ponomarova Olga, Starbard Alyxandra N, Belfi Alexandra, Anderson Amanda V, Sundaram Meera V, Walhout Albertha Jm

Abstract excerpt

In humans, a neomorphic isocitrate dehydrogenase mutation (idh-1neo) causes increased levels of cellular D-2-hydroxyglutarate (D-2HG), a proposed oncometabolite. However, the physiological effects of increased D-2HG and whether additional metabolic changes occur in the presence of an idh-1neo mutation are not well understood. We created a Caenorhabditis elegans model to study the effects of the idh-1neo mutation...

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Identifiers

PMID: 39009411
DOI: 10.26508/lsa.202402924
PMCID: PMC11249921

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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