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Article

Bacterial purine metabolism modulates C. elegans development and stress tolerance via DAF-16.

The FEBS journal - 1 Jun 2025

Feng Min, Gao Baizhen, Garcia L Rene, Sun Qing

Abstract excerpt

The purine metabolism is crucial for cellular function and is a conserved metabolic network from prokaryotes to humans. While extensively studied in microorganisms like yeast and bacteria, the impact of perturbing dietary intermediates from the purine biosynthesis on animal development and growth remains poorly understood. We utilized Caenorhabditis elegans as the metazoan model to investigate the mechanisms...

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Identifiers

PMID: 39708289
DOI: 10.1111/febs.17363
PMCID: PMC12138172

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