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Gut Microbial Genetic Variation Regulates Host Reproduction.

Microbial biotechnology - 1 Oct 2025

Ding Xiaoyue, Wu Yalun, Zhou Dianshuang, Gu Rongrong, Zhu Tao, Cai Wen, Ren Yuxuan, Li Ying, Wang Chuhe, Tan Anqi, Li Ying, Zhu Zuobin

Abstract excerpt

The gut-testis axis enables gut microbes to influence host reproduction; nonetheless, the specific role of microbial genetic variation in this process remains elusive. In this study, using Caenorhabditis elegans (C. elegans) as a model organism, we identified 46 Escherichia coli (E. coli) strains that markedly enhanced C. elegans fertility. Of them, 26 strains were mutant variants capable of mitigating...

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Identifiers

PMID: 41070630
DOI: 10.1111/1751-7915.70248
PMCID: PMC12511951

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