Article
Tissue-resident macrophages in the intestine are long lived and defined by Tim-4 and CD4 expression.
The Journal of experimental medicine - 4 Jun 2018
Shaw Tovah N, Houston Stephanie A, Wemyss Kelly, Bridgeman Hayley M, Barbera Thomas A, Zangerle-Murray Tamsin, Strangward Patrick, Ridley Amanda J L, Wang Ping, Tamoutounour Samira, Allen Judith E, Konkel Joanne E, Grainger John R
Abstract excerpt
A defining feature of resident gut macrophages is their high replenishment rate from blood monocytes attributed to tonic commensal stimulation of this site. In contrast, almost all other tissues contain locally maintained macrophage populations, which coexist with monocyte-replenished cells at homeostasis. In this study, we identified three transcriptionally distinct mouse gut macrophage subsets that segregate...
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