Article

Pamiparib induces neurodevelopmental defects and cerebral haemorrhage in zebrafish embryos via inhibiting notch signaling

2022-04-11

Abstract excerpt

<title>Abstract</title> <p>Pamiparib is a PARP inhibitor used in clinical studies, which can penetrate the blood-brain barrier efficiently. At present, there are few studies on its effect on vertebrate neurodevelopment. In this study, we exposed zebrafish embryos to 1, 2 and 3 µM of Pamiparib from 6 to 72 hours post-fertilization (hpf). Results showed that Pamiparib can specifically induce cerebral haemorrhage, b...

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Literature Corpus work: 44db4131-2cf5-53ff-8051-c85845a00aa8
DOI: 10.21203/rs.3.rs-1502031/v1

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Pamiparib induces neurodevelopmental defects and cerebral haemorrhage in zebrafish embryos via inhibiting notch signalingDOI 10.21203/rs.3.rs-1502031/v1Read

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