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Article

Aspirin reduces Ponatinib-induced cardiovascular toxic phenotypes and death in zebrafish.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Nov 2024

Yu Ruiqi, Ai Nana, Huang Chen, Wang Danni, Bian Chao, Ge Wei, Chong Cheong-Meng

Abstract excerpt

BACKGROUND: Ponatinib (Iclusig) is an oral tyrosine kinase BCR-ABL inhibitor for treating patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) and chronic myeloid leukemia (CML) who are resistant to the therapies with other tyrosine kinase inhibitors. However, adverse cardiovascular events caused by Ponatinib are a serious issue that affects patients' survival rates. Thus, it is...

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PMID: 39357328
DOI: 10.1016/j.biopha.2024.117503

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