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Article

Sex differences in the effects of PARP inhibition on microglial phenotypes following neonatal stroke.

Brain, behavior, and immunity - 1 Oct 2018

Charriaut-Marlangue Christiane, Leconte Claire, Csaba Zsolt, Chafa Linda, Pansiot Julien, Talatizi Mustapha, Simon Kristin, Moretti Raffaella, Marchand-Leroux Catherine, Baud Olivier, Besson Valérie C

Abstract excerpt

Neonatal acute ischemic stroke is a cause of neonatal brain injury that occurs more frequently in males, resulting in associated neurobehavioral disorders. The bases for these sex differences are poorly understood but might include the number, morphology and activation of microglia in the developing brain when subjected to stroke. Interestingly, poly (ADP-ribose) polymerase (PARP) inhibition preferentially...

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PMID: 29852289
DOI: 10.1016/j.bbi.2018.05.022

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MBP

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