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Article

Retinoic Acid Protects and Rescues the Development of Zebrafish Embryonic Retinal Photoreceptor Cells from Exposure to Paclobutrazol.

International journal of molecular sciences - 11 Jan 2017

Wang Wen-Der, Hsu Hwei-Jan, Li Yi-Fang, Wu Chang-Yi

Abstract excerpt

Paclobutrazol (PBZ) is a widely used fungicide that shows toxicity to aquatic embryos, probably through rain-wash. Here, we specifically focus on its toxic effect on eye development in zebrafish, as well as the role of retinoic acid (RA), a metabolite of vitamin A that controls proliferation and differentiation of retinal photoreceptor cells, in this toxicity. Embryos were exposed to PBZ with or without RA from 2...

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Share to Dose-Response Relationship, Drug
Share to Embryo, Nonmammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neuroprotective Agents

Share to Photoreceptor Cells, Vertebrate

Share to Retinal Pigment Epithelium

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Source

Open in PubMed Open full text

Identifiers

PMID: 28085063
DOI: 10.3390/ijms18010130
PMCID: PMC5297764

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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