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Repurposing Drugs for Senotherapeutic Effect: Potential Senomorphic Effects of Female Synthetic Hormones

2024-01-29

Abstract excerpt

Repurposing previously approved drugs may fast track the route to clinic for potential senotherapeutics and improves the inefficiency of the clinical drug development pipeline. We carried out a repurposing screen of 240 clinically approved molecules in human primary dermal fibroblasts for effects on CDKN2A expression. Molecules demonstrating effects on CDKN2A expression underwent secondary screening for senescence...

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Literature Corpus work
44a916c7-99d2-5d92-b976-09cbc34f352c
DOI
10.20944/preprints202401.2003.v1
Open publication

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Repurposing Drugs for Senotherapeutic Effect: Potential Senomorphic Effects of Female Synthetic HormonesDOI 10.20944/preprints202401.2003.v1
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