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Article

Effects of senolytic drugs on human mesenchymal stromal cells

18 Apr 2018

Abstract excerpt

BACKGROUND: Senolytic drugs are thought to target senescent cells and might thereby rejuvenate tissues. In fact, such compounds were suggested to increase health and lifespan in various murine aging models. So far, effects of senolytic drugs have not been analysed during replicative senescence of human mesenchymal stromal cells (MSCs). METHODS: In this study, we tested four potentially senolytic drugs: ABT-263...

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Share to Epigenetics and DNA Methylation
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PMID: 29669575
DOI: 10.1186/s13287-018-0857-6

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