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Senotherapeutic peptide treatment reduces biological age and senescence burden in human skin models

22 May 2023

Abstract excerpt

Cellular senescence is known to play a role in age-related skin function deterioration which potentially influences longevity. Here, a two-step phenotypic screening was performed to identify senotherapeutic peptides, leading to the identification of Peptide (Pep) 14. Pep 14 effectively decreased human dermal fibroblast senescence burden induced by Hutchinson-Gilford Progeria Syndrome (HGPS), chronological aging,...

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PMID: 37217561
DOI: 10.1038/s41514-023-00109-1

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