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Article

The role of cellular senescence in ovarian aging

20 Jul 2024

Abstract excerpt

This review explores the relationship between ovarian aging and senescent cell accumulation, as well as the efficacy of senolytics to improve reproductive longevity. Reproductive longevity is determined by the age-associated decline in ovarian reserve, resulting in reduced fertility and eventually menopause. Cellular senescence is a state of permanent cell cycle arrest and resistance to apoptosis. Senescent cells...

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PMID: 39033161
DOI: 10.1038/s41514-024-00157-1

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