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The role of cellular senescence in female reproductive aging and the potential for senotherapeutic interventions

11 Nov 2021

Abstract excerpt

BACKGROUND: Advanced maternal age is associated with decreased oocyte quantity and quality as well as uterine and placental dysfunctions. These changes lead to infertility, pregnancy complications and birth defects in the offspring. As the mean age of giving birth is increasing worldwide, prevention of age-associated infertility and pregnancy complications, along with the more frequent use of ART, become...

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PMID: 34918084
DOI: 10.1093/humupd/dmab038

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