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Cellular Senescence in Human Skin Aging: Leveraging Senotherapeutics

25 Oct 2023

Abstract excerpt

BACKGROUND: As the largest organ in the human body, the skin is continuously exposed to intrinsic and extrinsic stimuli that impact its functionality and morphology with aging. Skin aging entails dysregulation of skin cells and loss, fragmentation, or fragility of extracellular matrix fibers that are manifested macroscopically by wrinkling, laxity, and pigmentary abnormalities. Age-related skin changes are the...

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PMID: 37879300
DOI: 10.1159/000534756

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