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A Standardized In Vitro Platform for Senolytic Drug Discovery in Human Musculoskeletal Cells

2026-08-21

Abstract excerpt

Cellular senescence contributes to the progression of many age related musculoskeletal diseases. Cellular senescence is a biological state that arises from replicative exhaustion and various cellular stressors, including elevated oxidative stress, mitochondrial dysfunction, mechanical overload, and chronic exposure to pro-inflammatory cytokines and proteases. Although senolytic agents show promise for eliminating...

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Literature Corpus work
a5c6bef6-0e36-549c-bb7e-62189720b58a
DOI
10.64898/2026.08.20.746082
Open publication

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A Standardized In Vitro Platform for Senolytic Drug Discovery in Human Musculoskeletal CellsDOI 10.64898/2026.08.20.746082
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