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Periventricular Diffusivity Reflects APOE4-modulated Amyloid Accumulation and Cognitive Impairment in Alzheimer’s Continuum

2025-04-30

Abstract excerpt

<h4>Background</h4> Altered glymphatic-related fluid dynamics are increasingly recognized as a key feature of Alzheimer’s disease (AD). We generalized an established diffusion imaging technique to estimate periventricular diffusivity (PVeD), hypothesizing that fast diffusion signals in the periventricular region can reflect amyloid-beta (Aβ) deposition across the Alzheimer’s continuum. <h4>Methods</h4> Participa...

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Literature Corpus work
4483f2cf-6ce7-5659-80da-9265c6a23730
DOI
10.1101/2025.04.28.651021
Open publication

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Periventricular Diffusivity Reflects APOE4-modulated Amyloid Accumulation and Cognitive Impairment in Alzheimer’s ContinuumDOI 10.1101/2025.04.28.651021
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