Article

Ventricular expansion, white matter hyperintensities, and global cognition in Alzheimer’s disease and normal aging

2020-11-30

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> The progression of Alzheimer’s Disease (AD) may be tracked by measuring the growth of the ventricular cerebrospinal fluid (vCSF) over time. AD is commonly comorbid with markers of cerebral small vessel disease (SVD), viewed on MRI as white matter hyperintensities (WMH). Larger WMH volumes are correlated with poorer cognitive test scores. Additionally, periventricular WMHs have...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d9def2ca-f28d-5e33-b685-6eedab49557c
DOI: 10.1101/2020.11.30.20240879

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Ventricular expansion, white matter hyperintensities, and global cognition in Alzheimer’s disease and normal agingDOI 10.1101/2020.11.30.20240879Read

Association of MRI-measured cerebral ventricular volume with APOE ε4 genotype, cerebrospinal fluid biomarkers (Aβ42 and Tau) and neuropsychological measures in Alzheimer’s disease: A Systematic ReviewSemantic proximity Read

Contribution of white matter hyperintensities to ventricular enlargement in older adultsSemantic proximity Read

White Matter Hyperintensities, Grey Matter Atrophy, and Cognitive Decline in Neurodegenerative DiseasesSemantic proximity Read

The Temporal Relationships between White Matter Hyperintensities, Neurodegeneration, Amyloid β, and CognitionSemantic proximity Read

Alterations in MRI-visible perivascular spaces precede dementia diagnosis by 18 years in autosomal dominant Alzheimer's disease.Semantic proximity Read

White Matter Hyperintensity Distribution Differences in Aging and Neurodegenerative Disease CohortsSemantic proximity Read

Impact of white matter hyperintensities on subjective cognitive decline phenotype in a diverse cohort of cognitively normal older adults.Semantic proximity Read

Characterizing spatiotemporal white matter hyperintensity pathophysiology in vivo to disentangle vascular and neurodegenerative contributionsSemantic proximity Read

Multidomain determinants of perivascular spaces indicate early cerebrovascular vulnerability in individuals at risk of Alzheimer’s diseaseSemantic proximity Read

Serial MRI and CSF biomarkers in normal aging, MCI, and AD.Semantic proximity Read

Periventricular Diffusivity Reflects APOE4-modulated Amyloid Accumulation and Cognitive Impairment in Alzheimer’s ContinuumSemantic proximity Read

White matter hyperintensities are a core feature of Alzheimer's disease: Evidence from the dominantly inherited Alzheimer network.Semantic proximity Read