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Article

Alterations in MRI-visible perivascular spaces precede dementia diagnosis by 18 years in autosomal dominant Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Aug 2025

Leone Riccardo, Kobeleva Xenia, Rowe Bryan, Choupan Jeiran, Ringman John M, Barisano Giuseppe

Abstract excerpt

INTRODUCTION: Perivascular space (PVS) alterations are traditionally linked to cardiovascular risk factors and aging, but may also play a direct role in Alzheimer's disease (AD). To reduce confounding from age-related comorbidities, we examined PVSs in autosomal dominant AD (ADAD). METHODS: In this cross-sectional study of 96 non-demented individuals (62 mutation carriers), we quantified PVS count fraction and...

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Identifiers

PMID: 40851076
DOI: 10.1002/alz.70588
PMCID: PMC12375433

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