Article

Periventricular diffusion gradient of normal-appearing white matter and its transcriptional signatures in normal aging and multiple neurological diseases

2022-11-11

Abstract excerpt

<title>Abstract</title> <p>Abnormal periventricular gradient of normal-appearing white matter (NAWM) is a common WM signature of aging and multiple neurological diseases. Here, we investigated the periventricular gradient of NAWM and its association with brain-wide gene expression in middle-aged and elderly participants with Alzheimer's disease, Parkinson's disease, cerebral small vessel disease, and multiple scl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6ebd418a-73d1-5ea0-9c60-af5e4d5c2d36
DOI: 10.21203/rs.3.rs-2224463/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Periventricular diffusion gradient of normal-appearing white matter and its transcriptional signatures in normal aging and multiple neurological diseasesDOI 10.21203/rs.3.rs-2224463/v1Read

Periventricular Diffusivity Reflects APOE4-modulated Amyloid Accumulation and Cognitive Impairment in Alzheimer’s ContinuumSemantic proximity Read

Diffusion imaging genomics provides novel insight into early mechanisms of cerebral small vessel disease.Semantic proximity Read

Genetic and Phenotypic Architecture of Brain Glymphatic SystemSemantic proximity Read

Genome-wide and phenome-wide studies provided insights into brain glymphatic system function and its clinical associationsSemantic proximity Read

Characterizing spatiotemporal white matter hyperintensity pathophysiology in vivo to disentangle vascular and neurodegenerative contributionsSemantic proximity Read

Characterization of early white matter changes in CADASIL using microscopic diffusion imaging and relaxometrySemantic proximity Read

Transcriptomic, cellular, and functional signatures of white matter damage in Alzheimer’s diseaseSemantic proximity Read

Gray matter microstructure from in-vivo diffusion MRI reflects post-mortem neuropathology severity and clinical progression of Alzheimer’s diseaseSemantic proximity Read

Age differences in brain white matter microstructure in UK Biobank (N = 3,513)Semantic proximity Read

Molecular profiling of frontal and occipital subcortical white matter hyperintensities in Alzheimer’s diseaseSemantic proximity Read

Mapping the Microstructure of Human Cerebral Cortex In Vivo with Diffusion MRISemantic proximity Read

Diffusion-relaxation MRI as virtual histology: separable microstructural signatures of AD pathology in ex vivo human brainSemantic proximity Read