Article

Analysis of intratumoral immune heterogeneity reveals spatial organisation of immunosuppression in breast cancer

2025-12-22

Abstract excerpt

<h4>ABSTRACT</h4> Recent advances in single-cell transcriptomics have illuminated intratumoral heterogeneity (ITH) in breast cancer, yet the spatial organization and functional states of immune populations within luminal tumors remain poorly understood. Here, we generated a spatially and clonally resolved single-cell immune atlas of early-stage luminal breast cancer by integrating paired single-cell RNA/TCR seque...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 448212ef-8d97-58bf-8fd3-d885121b582d
DOI: 10.64898/2025.12.18.694622

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Analysis of intratumoral immune heterogeneity reveals spatial organisation of immunosuppression in breast cancerDOI 10.64898/2025.12.18.694622Read

Clonal expansion of intra‐epithelial T cells in breast cancer revealed by spatial transcriptomicsSemantic proximity Read

A comprehensive single-cell map of T cell exhaustion-associated immune environments in human breast cancerSemantic proximity Read

Characterizing the Tumor Microenvironment and Its Prognostic Impact in Breast Cancer.Semantic proximity Read

Characterizing tertiary lymphoid structures associated single-cell atlas in breast cancer patientsSemantic proximity Read

Integration of single-cell RNA and protein data identifies novel clinically-relevant lymphocyte phenotypes in breast cancersSemantic proximity Read

A comprehensive single-cell map of T cell exhaustion-associated immune environments in human breast cancer.Semantic proximity Read

A highly resolved integrated single-cell atlas of human breast cancersSemantic proximity Read

Immune organization defines adaptive immune competence and clinical outcome in breast cancerSemantic proximity Read

A Single-Cell Tumor Immune Atlas for Precision OncologySemantic proximity Read

Immunogenomic Landscape in Breast Cancer Reveals Immunotherapeutically Relevant Gene Signatures.Semantic proximity Read

Breast Cancer Macrophage Heterogeneity and Self-renewal are Determined by Spatial LocalizationSemantic proximity Read

Deciphering the spatial landscape and plasticity of immunosuppressive fibroblasts in breast cancerSemantic proximity Read