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Immunogenomic Landscape in Breast Cancer Reveals Immunotherapeutically Relevant Gene Signatures.

Frontiers in immunology - 1 Jan 2022

Wang Tao, Li Tianye, Li Baiqing, Zhao Jiahui, Li Zhi, Sun Mingyi, Li Yan, Zhao Yanjiao, Zhao Shidi, He Weiguang, Guo Xiao, Ge Rongjing, Wang Lian, Ding Dushan, Liu Saisai, Min Simin, Zhang Xiaonan

Abstract excerpt

Breast cancer is characterized by some types of heterogeneity, high aggressive behaviour, and low immunotherapeutic efficiency. Detailed immune stratification is a prerequisite for interpreting resistance to treatment and escape from immune control. Hence, the immune landscape of breast cancer needs further understanding. We systematically clustered breast cancer into six immune subtypes based on the mRNA...

Topics

Biomarkers, Tumor
Breast Neoplasms
Cohort Studies
Female
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Genome
Humans
Immunophenotyping
Immunotherapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphocytes, Tumor-Infiltrating

Mutation

Prognosis

Transcriptome

Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 35154121
DOI: 10.3389/fimmu.2022.805184
PMCID: PMC8829007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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